International Scientific & Medical Advisory Committee
CADASIL Together We Have Hope is honored to have a Scientific Medical Advisory Committee comprised of respected practitioners, researchers, and leading experts who are knowledgeable about CADASIL and similar disorders. This international group provides on-going information and support to the organization, which in turn is shared with the CADASIL community via this website, newsletters, and conferences. The non-profit extends an enormous thank you Dr. Hugues Chabriat, Dr. James Grotta, Dr. Raj Kalaria, Dr. Keith Muir, Dr. Leonard Pantoni, Dr. Stephen Salloway, Dr. Viera Saly, Dr. Swathi Sathe, Dr. Anad Viswanathan, and Dr. Michael Wang for volunteering their time towards the organization's mission.
Dr. Hugues Chabriat
Professor of Neurology at the University Paris VII in France. He is the Head of the Department of Neurology in University Hospital Lariboisiere (Paris) and the Coordinator of the Referral Centre for Rare Cerebrovascular Diseases (www.cervco.fr) in France. He received his MD from the Medicine Faculty "Cochin-Port Royal" and his PhD in Neuroscience from the Faculty of Science "Jussieu" at the University Paris VI. Dr. Chabriat is working with Professor Marie Germaine Bousser and has collaborated with Professor Elizabeth Tournier-Lasserve as well as Dr. Anne Joutel within "the French CADASIL team" for many years. He participated in the discovery of CADASIL and the identification of the mutated gene performed by the geneticists in France. His main research focuses on the imaging features of strokes particularly in small vessel diseases. He has made multiple contributions on the clinical, neuropsychological and imaging features of CADASIL and works on the dismantlement of small vessel diseases of undetermined origin. http://www.cervco.fr/en/activite-recherche/study-patients-mutation-gene-responsible-cadasil
Dr. James Grotta
Professor of Neurology at the University of Texas Medical School at Houston and Director of the Stroke Program at Memorial Hermann - Texas Medical Center. He was named the American Heart Association's Physician of the Year in 2006. He occupies the Roy M. and Phyllis Gough Huffington Distinguished Chair in Neurology which is funded by the National Institutes of Health with grants to carry out research from the laboratory to the bedside as well as train new fellows in the field of strokes. Dr. Grotta received his training at the Universities of Virginia and Colorado in addition to the Massachusetts General Hospital. He joined the University of Texas Houston Medical School faculty in 1979. His research focuses on development of new therapies for acute stroke patients. This includes experimental laboratory studies on the biology of brain injury, recovery after strokes, and approaches to reducing brain damage and improving recovery after strokes. He has also orchestrated the development of a collaborative network between University of Texas, Memorial Hermann Hospital, Houston Fire Department Emergency Medical Services, and other regional stroke centers to increase the delivery of appropriate therapy to a larger number of acute stroke patients. Dr. Grotta has an active clinical practice based at Memorial Hermann Hospital focused on stroke treatment and prevention and is a frequent invited lecturer at national and international meetings and symposia for the work he and his team have done in Houston.
Dr. Raj Kalaria
Professor of Neuropathology (Cerebrovascular Pathology) at the University of Newcastle upon Tyne, UK and the Institute for Aging and Health, Newcastle General Hospital. He obtained his doctoral qualifications from King’s College, University of London, and the Royal College of Pathologists, UK, before completing training in the United States. Professor Kalaria’s main scientific interests lie in risk factors and the neuropathologies of vascular dementia including CADASIL and Alzheimer’s disease. Professor Kalaria has published over 200 peer-reviewed articles and is the editor of two books. He also serves as associate editor on the editorial boards of Alzheimer Disease and Associated Disorders as well as NeuroReport journals. He served as Honorary Secretary of the British Neuroscience Association from 2000-2004. He presently serves on the executive and scientific boards of the International Society for Vascular Cognitive and Behavioral Disorders, and the International Brain Research Organization.
Dr. Keith Muir
Major interests are in the treatment of acute stroke and the application of advanced brain imaging techniques to aid treatment decisions in acute stroke; thrombolysis for stroke; clinical trials and clinical trial design in acute stroke; and the inherited syndrome CADASIL (Cerebral Autosomal Dominant Arteripathy with Subcortical Infarction and Leucoencephalopathy). Research work is predominantly undertaken in the South Glasgow Acute Stroke Service, based in the Institute of Neurological Sciences, where we have established a unit with the highest rates of IV thrombolytic treatment in the UK (and in the top 10 in Europe). Currently, we use a mixture of advanced imaging techniques including CT perfusion and CT angiography, MRI (including novel sequences being developed locally for metabolic imaging) and TCD. The specific techniques depend upon the individual research question – recent work has included the use of MR spectroscopy and DWI lesion volume evolution to investigate the therapeutic effects of insulin treatment for hyperglycaemia in acute stroke, and ongoing studies are investigating the influence of hyperglycaemia on recanalisation and reperfusion rates in acute stroke.
Dr. Leonard Pantoni
Department of Neurological and Psychiatric Sciences, University of Florence, Italy. Currently staff neurologist at the Department of Neurological and Psychiatric Sciences of the University of Florence where he is also Professor at the School of Neurology and the School of Child Neuropsychiatry. Dr. Pantoni studied medicine at the University of Florence and graduated in 1989. He was trained in neurology at the School of Neurology of the same University under the guidance of Domenico Inzitari and became a certified neurologist in 1993. From August 1993 to July 1995 he held a research fellowship in neuropathology at the Henry Ford Hospital in Detroit, Michigan, under the tutelage of Julio H. Garcia. In 1999 he received his PhD degree in Neuroscience. After this he received his current position as a staff neurologist at the Department of Neurological and Psychiatric Sciences of the University of Florence. Dr. Pantoni has always been interested in clinical neurology. He has focused his research work on vascular dementia and cerebral white matter changes of which he has explored definitions, radiological and pathological correlates, and therapeutic approaches. He also has a specific interest in experimental brain ischemia as it relates to the study of white matter lesions and cognitive changes. From 1996 to 2002 he has acted as scientific secretary of the European Task Force on Age-Related White Matter Changes, a multi-national association of the most prominent European experts on the topic. Today, he is deputy coordinator of the European Union funded study LADIS (Leukoaraiosis and Disability). In July 2003, he has been elected member of the Board of Directors of the International Psychogeriatric Association. He is also member of the Scientific Committee of the European Stroke Conference. Over the last years, Dr. Pantoni has served as reviewer for the following journals: the Lancet, JAMA, Stroke, Journal of Cerebral Blood Flow and Metabolism, Neurology, Neurobiology of Aging, and Journal of Neurology. He was also elected to the IPA Board of Directors in 2003. Dr. Pantoni’s publications include over 60 papers and abstracts on cerebrovascular disease in journals such as Stroke, Neurology, the Journal of Neurological Science, Cerebrovascular Diseases, Lancet Neurology, and Brain Research.
Dr. Stephen Salloway
Director of Neurology and the Director of the Aging and Memory Program at Butler Hospital. He is Professor of Neurology and Psychiatry at the Warren Alpert Medical School of Brown University. He received his MD from Stanford Medical School and completed residencies in neurology and psychiatry at Yale Medical School. Dr. Salloway has published more than 160 scientific articles, book chapters, and abstracts including 3 books. He is the Past President of the American Neuropsychiatric Association, a fellow of the American Academy of Neurology, and a member of the American Neurological Association. He serves on national and international committees to develop criteria for stroke and vascular dementia. He is a scientific reviewer for the National Institutes of Health as well as for more than 25 journals, universities, and research foundations. Dr. Salloway lectures widely on CADASIL, dementia, and neuropsychiatric disorders. Dr. Salloway has received numerous grants for his research which focuses on a) clinical trials for prevention and treatment of vascular dementia, Alzheimer's disease, and mild cognitive impairment, b) studies of genetic and sporadic forms of microvascular brain disease and c) assessment of frontal behavior and executive function. Under his direction, the Butler Memory and Aging Program has become a national referral center for the study of CADASIL. Dr. Salloway has established a CADASIL tissue bank in collaboration with colleagues in the Pathology Department at Brown. Studies with CADASIL brain tissue are leading to advances in understanding the molecular causes of small artery degeneration in CADASIL, which will hopefully lead to new treatments in the future. Dr. Salloway recently collaborated with an international group of CADASIL researchers to design and conduct the first controlled trial for CADASIL. http://research.brown.edu/myresearch/Stephen_Salloway
Dr. Viera Saly
completed MD and neurology training in Czechoslovakia and MSc degree (neuroanatomy)an internship and neurology residency at Queen's University, Kingston, Ontario. Since 1998 she has worked in Victoria B.C. as a general neurologist in private practise. Victoria General Hospital and Stroke Rapid Assessment Unit. She is a Clinical Assistant Professor at UBC/Island Medical School. She has special interest in CADASIL and serves as medical advisor for Canadian CADASIL Foundation.
Dr. Swati Sathe
Assistant Professor of Neurology in the department's Neurogenetics Division at New York University. Dr. Sathe received her medical training at the University of Mumbai and New York University. She has authored several journal articles. Dr. Sathe planned and organized the first ever U.S.A. CADASIL Symposium on July 30, 2010.
Dr. Anand Viswanathan
Dr. Viswanathan is a member of the Massachusetts ADRC and a staff neurologist at the Stroke Service and Memory Disorders Unit at the Massachusetts General Hospital. He received his MD, PhD in medicine and molecular genetics from Emory University, and was trained in internal medicine at the Beth Israel Deaconess Medical Center prior to his residency program in vascular neurology at the Massachusetts General Hospital and the Brigham and Women's Hospital. Dr. Viswanathan served as a clinical research fellow with Professors Marie-Germaine Bousser and Hugues Chabriat at the Hôpital Lariboisière in Paris from 2005-2006, and his group actively collaborates with colleagues at the Hôpital. Dr. Viswanathan's research interests include studying the contributions of stroke and vascular risk factors to dementia. Interests: Stroke, memory disorders, cerebral amyloid angiopathy (CAA), cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Dr. Michael Wang
Assistant professor of neurology and director of molecular stroke research in the Department of Neurology at the University of Michigan. He also is an assistant professor of molecular and integrative physiology at the U-M and a physician in neurology at the VA Ann Arbor Healthcare System.Dr. Wang's research includes laboratory investigations into the molecular basis of stroke and the interaction between stroke, circadian rhythms and disordered sleep. A major interest of the lab is investigating the causes and treatment of CADASIL (Cerebral Autosomal Dominant Arteriopathy Subcortical Infarcts and Leukoencephalopathy), a devastating inherited cause of stroke and vascular dementia. His other interests include studies of the functions of endogenous hormones (estrogen) and differentiation factors on neurons. He received his bachelor's degree, summa cum laude, from Harvard University and earned his medical degree and doctorate in molecular biology and genetics from Johns Hopkins University (JHU) in 1994. In 1998, he completed his neurology residency at JHU; in 2000, he completed a stroke research fellowship with Drs. Richard Traystman and Patricia Hurn. Dr. Wang spent three years on the neurology faculty at JHU before joining the U-M faculty in 2003. During his time at JHU, he also served as a staff neurologist at the Johns Hopkins Hospital and the Johns Hopkins Bayview Medical Center, both in Baltimore, Maryland. Dr. Wang was elected to Phi Beta Kappa during his junior year at Harvard and to Alpha Omega Alpha at JHU. While a fellow, he was awarded funding from the National Stroke Association and the American Heart Association, and also received a Burroughs Welcome Career Award in Biomedical Sciences. His research has been supported by the National Institutes of Health (NIH) since 2001. He has published his scientific work in Nature, Journal of Neuroscience and Stroke, and has served as a member of national grant review committees of the NIH and the American Heart Association. His bibliography includes more than 20 peer-reviewed publications, seven book chapters, and numerous abstracts and clinical papers. He also is an ad hoc reviewer for the Journal of Cerebral Blood Flow and Metabolism, American Journal of Physiology, Stroke, and Neurology, among others.At the U-M, Dr. Wang is involved in medical student pre-clinical education, resident education and clinical studies conducted by the U-M Brain Injury Group. He is a member of the Stroke Council of the American Heart Association and a member of the Society of Neuroscience.