CADASIL Tissue Bank and Brain Donations             

Studies with CADASIL brain tissue are leading to advances which, will hopefully result in new treatments and a possible cure in the future.'

These banks are supported by brain and tissue donations by surviving families of CADASIL patients.

Please note we do not directly support any individual, organization, hospital, or research team but rather provides information for you to make an educated decision. 

Tissue and Protein Project

The University of Michigan has federal grants to study CADASIL from the NIH (National Institute of Health) and the Veterans Administration. Dr. Wang is studying proteins that accumulate with Notch3 in the vessels of the brain. Identifying these proteins gives them an insight into possible targets for therapy for CADASIL patients. Dr. Michael Wang states, “We have been really aided recently by the availability of generous tissue donations from very special patients and families. We need additional tissue to strengthen our research. We are using the tissue to examine how Notch3 and other proteins deposit in the vessels of the brain. This is an elective and hard decision when a loved one passes away, but we feel that these tissue donations are extremely important for future advances in CADASIL." If you are interested in donating a loved one's brain for this most current research please contact:

Michael M. Wang M.D., Ph.D.,
Department of Neurology
Molecular & Integrative Physiology,
Ann Arbor, MI 48109
Phone: 734-845-5202
e-mail: micwang@umich.edu   

 

Tissue Bank

Dr. Stephen Salloway, a Professor of Neurology and Psychiatry at the Alpert Medical School of Brown University, has established a CADASIL Tissue Bank. The Memory and Aging Program, which he directs with Dr. Paul Malloy, is located at the Butler Hospital in Rhode Island and is affiliated with the Alpert Medical School of Brown University. Studies with CADASIL brain tissue are leading to advances in understanding the molecular causes of small artery degeneration in CADASIL, which will hopefully lead to new treatments in the future. This bank is supported by brain and tissue donation by surviving families of CADASIL patients. For more information please contact:

Stephen Salloway, M.D., M.S.
Director of the Memory and Aging Program, Butler Hospital
345 Blackstone Boulevard
Providence, RI 02906
Phone: (401) 455-6403
e-mail: SSalloway@Butler.org  

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