Among patients with CADASIL, how many genes are counted?


There is only one gene responsible for CADASIL, Notch3, located on chromosome 19. Any gene is compound of parts called exons. They are "building blocks" which issue a code to the cell fabrication proteins. Notch3 consists of 33 exons and mutations at different exons, which vary families. CADASIL is linked to a single gene, and there are many formats of mutations (more than one hundred) of this gene. (March 2011 General Assembly in Paris, France)

Date: March 2011

CADASIL France General Meeting (www.CADASIL.com)


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