Q:
Among patients with CADASIL, how many genes are counted?

A:

There is only one gene responsible for CADASIL, Notch3, located on chromosome 19. Any gene is compound of parts called exons. They are "building blocks" which issue a code to the cell fabrication proteins. Notch3 consists of 33 exons and mutations at different exons, which vary families. CADASIL is linked to a single gene, and there are many formats of mutations (more than one hundred) of this gene. (March 2011 General Assembly in Paris, France)

Date: March 2011

CADASIL France General Meeting (www.CADASIL.com)

 

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