What can the course of the disease, knowing that each patient's disease presents itself in different ways?

The evolution of the disease in a patient is not predictable. The monitoring protocol is designed to study this evolution. What we observe is that for a long time, the disease (clinical status) changed little. In general, when the disability (gait disturbance, poor concentration and memory) begins to manifest, there is an acceleration of evolution. A stroke is not a sign of worsening in functional terms, the recovery is good early in the disease. It is the accumulation of small infarcts, which explains the severity of the disease.  Very atypical cases have been encountered: some people the mutation show no symptoms at age 70. 

Return to questions