Q:
Is it that there may be a link between these three diseases: CADASIL, lower limb arteritis and ankylosing spondylitis according to the information because we had the gene mutated Notch3 is the cause of the fragility of the arteries?

A:
T he Notch3 gene is present in all the vessels of the body. He has a particular function in cerebral vessels, where there is a neuro-vascular coupling. Its mutation has an impact on neurovascular function and it is not causing problems that clog vessels in other organs. There is no link with peripheral arterial disease or with ankylosing spondylitis.


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